RHOA and cancer: PYK2 via binding to Rab22a-NeoF1 fusion protein is also enriched in exosomes, and the exosomal PYK2 induces RhoA activation in its recipient cancer cells negative for Rab22a-NeoF1 to promote migration, invasion, and lung metastases of these cancer cells (Fig. 4d–h and Supplementary Fig. 4d–g).