of Rab22a-NeoF1 was also responsible for the interaction of Rab22a-NeoF1 with PYK2, and the 1–10 a.a.-iRGD peptide abolished the exosomal Rab22a-NeoF1-mediated lung metastases of its negative recipient cells using the orthotopic osteosarcoma metastasis model (Fig. 8a–f). Here, PTK2B is linked to osteosarcoma.