RHOC and cancer: On the other hand, the intercellular activation of RhoA mediated by Rab22a-NeoF1 fusion protein in its positive cancer cells is achieved via its constitutively binding to SmgGDS607 to release RhoA to become active, as shown recently by our group.6RAB22A-NeoF1 fusion gene is expressed in cells, its protein is high enough to constitutively bind SmgGDS607, a specific noncanonical GEF protein for RhoA and RhoC,41 to facilitate the activation of RhoA.