Our findings are consistent with the literature, showing that Stat3 activation is critical for the polarization of M2 macrophage,33 and that PYK2 promotes cancer metastasis by forming a positive feedback loop with Stat3.34 Therefore, it is possible that cancer progression may be more complicated once some cancer cells are positive for any fusion protein, as the fusion protein may have multiple ways to accelerate cancer progression and subsequently accounts for patient outcome. The gene discussed is PTK2B; the disease is cancer.