SIRT6 and Leigh syndrome: When we compared gene expression levels in hypertrophic ligamentum flavum (LFH) and non-hypertrophic ligamentum flavum (LFN) tissue samples from LSS patients, we found that the expression of SIRT6 and of the telomere-related genes POT1 and TPP1 was significantly reduced in LFH samples relative to LFN samples through both transcriptomic high-throughput sequencing and qRT-PCR analyses (Figure 1 and Table 1).