T/F SHIV.C.CH848 infection in rhesus macaques during early and chronic infection closely mirrors HIV infection, as indicated by high peak viremia in primary infection, relatively stable viral set point of 104 to 105 viral RNA copies/ml of plasma, massive gut-associated mucosal CD4+ T cell depletion, stable proviral DNA in systemic and lymphoid tissues even after 6 months of cART, and viral rebound after treatment interruption. The gene discussed is CD4; the disease is HIV infectious disease.