Some of these monoallelic deletions include FAS (the cell death receptor), GOT1, and GLUD1 (involved in glutamine metabolism), PGAM1 (a glycolysis gene), HIF1AN (HIF1α inhibitor), and MGMT (a gene known to provide TMZ resistance in GBM through promoter methylation). This evidence concerns the gene PGAM1 and glioblastoma.