SHANK3 and premenstrual tension: Chromosomal disruptions of the SHANK3 gene within the critical region of 22q13.3 deletion syndrome (Phelan–McDermid syndrome; PMS) have been widely studied (Wilson et al., 2003), and chromosomal microdeletions of SHANK1 and SHANK2 genes have also been reported (Pinto et al., 2010; Sato et al., 2012).