CD274 and neoplasm: To analyze the immune cell landscape in the context of age at diagnosis, we used a combination of in silico deconvolution of RNAseq data based on the CIBERSORTx method, in situ analyses of PD-L1 and CD20 protein expression, whole-slide hemotoxylin and eosin-stained TIL infiltration estimates, and neoantigen expression and tumor mutational burden (TMB) estimates from WGS.