When considering the genetic background of HR deficiency (HRD), this decrease in Ki67 gene expression was, however, only statistically significant in HRDetect-low/intermediate patients (Kruskal-Wallis p = 0.03, linear regression p = 0.09, Additional file 1D-E). This evidence concerns the gene MKI67 and hypoparathyroidism-retardation-dysmorphism syndrome.