Accordingly, all cancers investigated in this work (i.e., pancreatic, triple negative breast, liver and colorectal cancer) that express high CD71 levels are more sensitive to The-0504 than free Genz-464,282 (Fig. 2 and S4); only the SJSA1 osteosarcoma cell line, which has low CD71 expression levels, is killed less effectively by The-0504 than by the free drug (Table 1 and Fig. S2). Here, TFRC is linked to cancer.