According to previous study, UHRF1 can regulate the epigenetic status of downstream genes through interacting with some epigenetic regulators such as DNMT1, DNMT3A, DNMT3B, EZH2, JMJD6, KDM6A and KDM6B [45], which may be involved in the regulation of BCL6 transcription in Tfh cells of SLE (Fig. 6). This evidence concerns the gene EZH2 and systemic lupus erythematosus.