FGFR2 and cholangiocarcinoma: For example, BGJ398 has been granted Fast Track Designation by FDA for treating cholangiocarcinoma with FGFR2 gene fusions due to the phase II study (NCT02150967) with an encouraging progression-free survival (PFS, 5.8 months), response rate (14.8%), and disease control rate (75.4%) [18].