Chell and his colleagues sequenced a KMS-11 myeloma cell line resistant to AZ12908010, and found the FGFR3 gatekeeper mutation V555M, which conferred cross-resistance to AZD4547 and PD173074 by an increase in FGFR3 phosphorylation and an improvement of downstream signaling transduction [34]. Here, FGFR3 is linked to plasma cell myeloma.