EPHB3 and gastric cancer: Lee et al. reported that the EphB3 signaling pathway was alternatively activated in FGFR inhibitor AZD4547 resistant gastric cancer cell line SNU-16R, thereby promoting epithelial-to-mesenchymal transition (EMT) of gastric cancer cell through activation of Ras-ERK1/2-mTOR pathway [96, 97].