The top 10 pathways obtained by KEGG analysis were: "cytokine-cytokine receptor interaction", "neuroactive ligand-receptor interaction", "Rap1 signaling pathway", "melanoma", "Ras signaling pathway", "Pathways in cancer", "MAPK signaling pathway", "PI3K-Akt signaling pathway", "Chemokine signaling pathway" and "Rheumatoid arthritis" (Fig. 1d). The gene discussed is AKT1; the disease is rheumatoid arthritis.