HNE modifications in four differential HNE-modified peptide adducts were validated by IP-Western blotting with two pooled Con A-captured serum samples from RA and HCs, which detected signals of approximately 184, 43, 25, and 80 kDa, respectively, indicating CFAH, HPT, IGKC, and THRB (Fig. 1). The gene discussed is IGKC; the disease is rheumatoid arthritis.