HNE modifications in four differential HNE-modified peptide adducts were validated by IP-Western blotting with two pooled Con A-captured serum samples from RA and HCs, which detected signals of approximately 184, 43, 25, and 80 kDa, respectively, indicating CFAH, HPT, IGKC, and THRB (Fig. 1). This evidence concerns the gene MRS2 and rheumatoid arthritis.