CD40LG and rheumatoid arthritis: Levels of IgM against HPT78−108 were 1.35-fold (p = 0.0013) greatly higher in RA patients than HCs (Fig. 3g, left panel), and AUC values were 0.67 (with 71.7% sensitivity and 56.7% specificity) for detecting RA and 0.53 (with 51.4% sensitivity and 50.0% specificity) for detecting OA (Table 2).