CD40LG and rheumatoid arthritis: Levels of anti-HPT78−108 HNE IgM in RA patients were greatly higher than the levels in OA patients by 3.45-fold (p < 0.0001), while RA patients versus HCs was 3.83-fold higher (p < 0.0001) (Fig. 3h, left panel), and AUC values were 0.89 (with 86.7% sensitivity and 66.7% specificity) for detecting RA and 0.58 (with 65.7% sensitivity and 55.0% specificity) for detecting OA (Table 2).