The AUC, sensitivity, and specificity were used to assess clinical performances of IgG and IgM that against unmodified and HNE-modified peptides.The ANOVA analysis indicated that differences in all autoantibodies against unmodified and HNE-modified peptides were significant among patients with RA, OA, and HCs (Fig. 3, Table 1). Here, CD40LG is linked to rheumatoid arthritis.