ENPP2 and pachyonychia congenita: Upon combining two or all three markers, the AUROC increased for the late tumor stage of PC, but the increase was not significant (CA19-9 and ATX vs. HV group, p = 0.4508) (CA19-9 and ATX vs. BPD group, p = 0.279) (ATX, LPA and CA19-9 vs. HV group, p = 0.1657) ( ATX, LPA and CA19-9 vs. BPD group, p = 0.136) ( Table 5 and Fig. 2).