IL6 and infection: 1) CRP is a protein not an inflammation cell and does not fully reflect the inflammatory process, it is only secreted by hepatocytes with an inflammatory state; 2) CRP is lagging in the inflammatory response and needs to be produced mainly by hepatocytes mediated by IL-6; 3) CRP is poorly measurable and in the face of inflammation CRP is generally elevated 10,000-fold, for example there is 0.8 mg/L elevated to 80,000 mg/L; 4) In fact, significant changes in CRP are only possible in the acute phase of severe infection or inflammation [18].