CD274 and esophageal squamous cell carcinoma: As shown in Table 3, univariable and multivariable analyses identified the following clinical factors as significant OS prognostic indictors in patients with ESCC: NLNs (adjusted HR 0.963, 95%CI 0.938–0.989, P = 0.006), pTNM stage (adjusted HR 1.987, 95%CI 1.050–3.761, P = 0.035), and the expression of PD-L1 (adjusted HR 4.746, 95%CI 2.669–8.438, P < 0.001).