MMP2 overexpression was significantly associated with higher histological grades (for grade 2–3 vs 1, OR = 2.11, P < 0.001; for grade 3 vs. 1–2, OR = 1.53, P = 0.005; Fig. 4), higher tumor stages (OR = 2.09, P = 0.001) and distant metastasis (OR = 2.69, P = 0.005), but not with the other clinicopathological features. This evidence concerns the gene MMP2 and neoplasm.