TP53 and neoplasm: In tumor suppression and apoptosis, eRNAs originating from p53-bound enhancer regions (p53BERs) are required for p53-dependent cell-cycle arrest; NamiRNA miR-17–92 suppresses chromatin regulatory genes (Sin3b, Hbp1, Suv420h1, and Btg1) and the apoptosis regulator (Bim) via similar TFs (such as AGO2 and FOXA1) to regulate cell survival and autonomous proliferation [89].