E. canis, identified in Italy only in samples from dogs, is the etiological agent of canine monocytic ehrlichiosis (CME), typically characterized by fever, depression, anorexia lymph adenomegaly, splenomegaly, hemorrhagic tendencies, pale mucosa, weight loss, ophthalmologic lesions, neurologic disorders, CBC abnormalities like anemia, leukopenia with lymphocytosis, hypoalbuminemia with hyperglobulinemia and increase in alanine aminotransferase, alkaline phosphatase and C-reactive protein [111,126,132,133,134,136,139,140,141,142]. The gene discussed is GPT; the disease is major depressive disorder.