In this context, the activities of GIVA-PLA2 (needed for the release of AA) and GVIA-PLA2 (needed for the release of DHA) and their isoenzymes such as iPLA2, sPLA2 and cPLA2 and COX-2 and LOX enzymes determine the final products that are formed from the released AA and DHA in the development of AD and its progression [211,212]. This evidence concerns the gene PTGS2 and Alzheimer disease.