CD59 and Alzheimer disease: It appears whenever there is a deficiency of AA/EPA/DHA, an increase in the production of PGE2, LTs and TXs would occur accompanied by a deficiency of LXA4, resolvins, protectins and maresins as observed in type 2 DM, hypertension, and CHD [35,36,117,155] (see Table 5), diseases in which LXA4 deficiency occurs and are commonly associated with AD.