Since aging increases the incidence of insulin resistance, obesity, hypertension, type 2 diabetes mellitus and cancer, it is reasonable to suggest that endothelial dysfunction, atherosclerosis, diabetes mellitus, hypertension, coronary heart disease and cancer are associated with an imbalance in the concentrations of pro- and anti-inflammatory bioactive lipids such that a deficiency of anti-inflammatory lipoxins, resolvins, protectins and maresins and NO (nitric oxide) and a relative increase of PGE2, PGF2α concentration occurs. This evidence concerns the gene CD59 and coronary artery disorder.