ENPP2 and neoplasm: More specifically, the activation of NF-kB in tumor cells enhances the expression of several genes (including Ccl7, Cxcl1, Ccl5, Slc39a10, Lcn2, Zc3h12a, and Enpp2) that are implicated in tumor migration, angiogenesis, and formation of pre-metastatic niches [5,148,149].