CDH1 and neoplasm: In addition, RAC1B promoted the expression of epithelial genes (i.e., CDH1) and inhibited that of mesenchymal and invasion-associated genes (i.e., VIM and SNAI2) [8], enhanced tumor-suppressive Smad signaling and inhibited tumor-promoting MEK-ERK signaling [8,10], and inhibited transforming growth factor β1 (TGFβ1)-induced EMT and cell invasion in both PDAC [9,10] and TNBC [11] cells.