By contrast, Wu et al. [97] have more recently shown that the expansion of CD4+ CD28− cells in SLE patients is negatively associated with disease activity—lupus low disease activity state is associated with lower anti-DNA levels—and that the polyfunctional CD8+ T-cell response to HCMV pp65 is not impaired. This evidence concerns the gene CD4 and systemic lupus erythematosus.