STAT4 and Autoimmunity: For example, the association between genetic polymorphisms related to cytokines, as single-nucleotide polymorphisms (SNPs) in signal transducer and activator of transcription 4 (STAT4) or interleukin 10 (IL-10), and different autoimmune disorders has been described [77,78,79], identifying IFN-α as an environmental modifier of the STAT4 risk allele and indicating a major risk to develop the disorder during a viral infection [80].