For example, patients affected by SSc express different autoantibodies able to recognize both cellular proteins and their homologous HCMV counterparts—e.g., anti-topoisomerase I/HCMV pUL70 [82] and anti-cell surface integrin–neuroblastoma-amplified gene (NAG)-2/HCMV pUL94 [83] antibodies. This evidence concerns the gene TSPAN4 and systemic sclerosis.