Notably, although the discussed ion transport proteins and mechanisms of intracellular pH regulation are indisputably essential for the key functions of neutrophils, the question of whether direct alterations of, for example, NHE1 or VSOP/Hv1 expression or activity actually do contribute to neutrophil dysfunction in severe sepsis has to date hardly been addressed and requires further research. This evidence concerns the gene HVCN1 and Sepsis.