We observed that LMWH can (1) reduce oxidative stress and restore antioxidant activity; (2) reduce the production of inflammatory cytokines MIP-2 and IL-6; (3) attenuate muscle proteolysis and apoptosis; (4) ameliorate mitochondrial injury and autophagy; and (5) restore ultrastructural integrity and diaphragm excursion and thickness in a mouse model of VIDD with endotoxemia. This evidence concerns the gene IL6 and serum lipopolysaccharide activity.