In our prior study of an animal ventilator-induced lung injury (VILI) model, LMWH substantially mitigated microvascular permeability, inflammatory cell infiltration, the production of active plasminogen activator inhibitor-1 (PAI-1), and acute lung injury (ALI) scores owing to its anti-inflammatory effects and beneficial mechanisms neutralizing dysregulated coagulation and fibrinolysis [27]. This evidence concerns the gene SERPINE1 and acute lung injury.