It is well known that both EMT and autophagy are the main biological processes in cancer initiation, progression, and metastasis [18].In the EMT process, Snail increases as a main regulator to promote the transcription of genes expressed in mesenchymal cells, while the epithelial marker Zonaoccludin-1 (ZO-1)is suppressed [19]. Here, SNAI1 is linked to cancer.