Figure S2 demonstrates that fibrosis is markedly increased in mice with BCG treatment compared to PBS treatment (WT/PBS/KLN205 vs WT/BCG/KLN205) and lung fibrosis after BCG injection is reduced in NOX4 KO mice compared to WT mice (NOX4 KO/BCG/KLN205 vs WT/BCG/KLN205). These findings are consistent with a previous study [5]. Here, NOX4 is linked to pulmonary fibrosis.