NOX4 and cancer: NOX4KO/PBS/KLN205 mice (NOX4 KO mice with KLN205 cancer cell injection after BCG treatment) showed a reduced number ofclusters of squamous lung cancer cells and decreased expression of Ki67 compared to NOX4WT/BCG/KLN205 mice (NOX4WT mice with KLN205 cancer cell injection after BCG treatment) (Figure 3B).