In addition, up-regulation of genes involved in tissue injury and hepatic fibrosis (Adora1) [28], caspase-dependent apoptosis (Moap1) [29], and oxidative stress and antioxidant defense (Ephx2 and Oxr1) [30] was identified only in the liver treated with Zn ions (Table 4). This evidence concerns the gene ADORA1 and Hepatic fibrosis.