In addition to SMAD1 (see above) (Figure 3B), promoter hypermethylation of seven cancer-related genes has been found in cHL: CDKN2A (77%), RASSF1A (59%), CDH1 (51%), DAPK (45%), GSTP1 (43%), SHP1 (also called PTPN6) (38%) and MGMT (24%) [41]. This evidence concerns the gene PTPN6 and cancer.