SOCS1 and classic Hodgkin lymphoma: Inactivating mutations, deletions and—especially in pediatric cHL [13]—inactivating translocations of SOCS1 and, rarely, SOCS6, both negative regulators of JAK/STAT signaling, can be found in up to 50% of NLPHL [34] and 60% of cHL [7,11,16,35].