Bona fide activating mutations of the nuclear shuttle protein XPO1 also contribute to the nuclear accumulation of STATs and have been found in 18%, 24% and 26% of the studied cHL cases, respectively [11,16,36], and patients with the detectable hotspot mutation XPO1 E571K even tended towards a shorter progression-free survival [36]. The gene discussed is XPO1; the disease is classic Hodgkin lymphoma.