Despite that there were no obvious and strong associations with lung function for TRPM8 rs11562975 in COPD, we took a closer look at this polymorphism since its influence on FEV1 and FEV1/FVC was established in our previous studies in asthma patients, including those with smoking history > 10 pack-years [28,33]. This evidence concerns the gene TRPM8 and asthma.