In this study, ALA did not significantly change the serum levels of pro-inflammatory biomarkers, such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), fundamental cytokines implicated in the pathogenesis of RA, C-reactive protein (hs-CRP), and matrix metalloproteinases (MMP-3). The gene discussed is TNF; the disease is rheumatoid arthritis.