RIPK1 and cancer: Furthermore as reported by the COSMIC database about the somatic mutations in cancer, RIPK1 gene is not significantly mutated in a specific tissue, rather, the identified mutations are: about 36% missense substitutions, 10% synonymous substitutions, 5% nonsense substitutions, 0.4% frameshift insertions, 0.2% frameshift deletions, and 9% of mutations without detailed information available [99].