COL6A2 and Brugada syndrome: However, in a cardiac evaluation of 50 LGMDD5 patients of 26 families, van der Kooi and colleagues reported one 37-year-old Dutch male with simultaneous mutations in COL6A2 and SNC5A. He presented with Brugada syndrome–like electrocardiographic findings with incomplete RBBB and ST-segment elevation in the right precordial leads.