Comparison of two groups of APS/healthy donors demonstrated the presence of APhL in 89.7/0%, anti-PI in 89.7/32.1%, anti-PS in 86.2/7.1%, aCL in 93.1/32.1%, and anti-β2GPI in 86.2/0%. The gene discussed is PRB2; the disease is autoimmune polyendocrinopathy.