These aPLs, described on Figure 1, include APS criteria antibodies of the lupus anticoagulant, anti-cardiolipin, anti-β2-glycoprotein-I type, and APS non-criteria antibodies of the anti-β2-glycoprotein-I domain I (anti-DI), anti-annexin V, anti-annexin II, anti-prothrombin (anti-PT), anti-phosphatidylserine/prothrombin (anti-PS/PT), anti-cardiolipin/vimentin (aCL/Vim), anti-protein S/protein C (anti-PS/PC) type, and others. This evidence concerns the gene ANXA5 and autoimmune polyendocrinopathy.