Chayoua et al. [46] analyzed a multicentric study of aPL detection in 1068 patients from 8 sites by 4 various methods (CLIA, ELISA, multiplex fluorescence flow immunoassay (MFFIA), fluorescence enzyme immunoassay (EliA)) and they determined isolated positivity of anti-β2GPI IgA in patients with clinical manifestations of APS in 0.3–5% dependent on the device used. Here, APOH is linked to autoimmune polyendocrinopathy.