ADORA2A and coronary artery disorder: PBMCs are a valuable surrogate for cardiovascular cells to study the adenosinergic profile in patients with CAD because the behavior of A2AR in the two cell types is similar in terms of A2AR level and cAMP production, which was reported for the left ventricle in cardiac transplant recipients, the aorta and coronary artery tissues, and femoral arteries [172,212,213].