Besides, growing evidence indicates that Sco interferes with extracellular signal-regulated kinase (ERK) and cAMP response element-binding (CREB)/brain-derived neurotrophic factor (BDNF) molecular homeostasis in animal models [13,14] while simulating ERK/CREB/BDNF injury in the brains of AD patients [15]. The gene discussed is CREB1; the disease is Alzheimer disease.