Indeed recently, Qin Q et al. and Quéro et al. have reported respectively 3 and 4 patients suffering from heavily pretreated and anti-PD-1-naïve Hodgkin lymphoma whom all underwent durable and complete response (CR) with association of palliative normofractioned RT and anti-PD-1 (the historical CR rate is estimated at 20%) [80,81]. This evidence concerns the gene PDCD1 and Hodgkins lymphoma.