In the present study, the age of patients with Alzheimer’s disease ranged from 60 to 106 (mean = 78.8 ± 4.2 years) and that of control subjects ranged from 41 to 79 (mean = 60.4 ± 7.8 years), although our analysis detected no age-dependence in the ACE2 protein expression (Figure 1F). Here, ACE2 is linked to early-onset autosomal dominant Alzheimer disease.