The ACE2/GAPDH ratio values obtained from 13 patients with Alzheimer’s disease ranged from 0.3 to 3 (mean = 1.2 ± 0.2), while those of control subjects were highly consistent with a mean of 0.26 ± 0.04 (Figure 2A). The gene discussed is GAPDH; the disease is early-onset autosomal dominant Alzheimer disease.