In our global expression and DNA-binding analysis in the colorectal cancer cell line DLD-1, we found that AP4 binds to the promoters of and up-regulates many EMT effectors and marker genes, such as SNAIL, Vimentin, FOS, LEF1, and N-cadherin, and directly represses CDH1/E-cadherin. The gene discussed is CDH1; the disease is colorectal cancer.