In summary, AP4 regulates the fate of cancer cells by forming regulatory networks with numerous signaling pathways, transcription factors, and ncRNAs, among them the Wnt and Notch pathways, c-Myc, p53, HDM2, miRNAs (miR-15a/16-1, miRNA-520f-3p), and lncRNAs (LINC00520, TRERNA1). This evidence concerns the gene TFAP4 and cancer.