SERPINE1 and Alzheimer disease: Genes in this network included Irf7, Birc3, Tnfsf10, Il6, Serpine1, and Tab1 (predicted to be the upstream regulator), which have been shown to be DE in brains of AD patients (Agora Consortium, 2020) and identified as targets for therapeutics (Costa et al., 2017; Romagnoli et al., 2020; Calandria et al., 2015; Riphagen et al., 2020; Cantarella et al., 2015; Kutz et al., 2012; Caraci et al., 2012).