DMD and Duchenne muscular dystrophy: Canine X-linked muscular dystrophy in Japan (CXMDJ), a beagle-based dystrophic dog, is a midsize mammalian translational model of DMD (Supplementary Fig. S1a) that mimics the human DMD phenotype more closely than the widely used dystrophin-deficient rodent models [13] and has been used to investigate molecular mechanisms triggering the physiopathological modifications in DMD [14–19].