The expression of CDKN1A in the cultivated BCC cells treatedwith 5-FU and the combination of MMC and 5-FU was higher than that in thecontrols (p=0.0001 and p=0.007, respectively).The expression of TP53 in the cultivated BCC cells treated withMMC was also higher than that in the controls (p=0.0001). The gene discussed is CDKN1A; the disease is skin basal cell carcinoma.