Of those, 161publications were excluded for not being original research, not focusing onhuman subjects, not examining PON1, or including subjects that did not have AMD.Nine publications that investigated the association between L55M or Q192Rpolymorphism and AMD remained; however, one study was excluded because the datawere used in a previous publication, and two were excluded for lack ofsufficient data. This evidence concerns the gene PON1 and age-related macular degeneration.