Hernández-Rodas MC, Valenzuela R, Echeverría F et al. Supplementation with docosahexaenoic acid and extra virgin olive oil prevents liver steatosis induced by a high-fat diet in mice through PPAR-α and Nrf2 upregulation with concomitant SREBP-1c and NF-kB downregulation. The gene discussed is SREBF1; the disease is fatty liver disease.