Zhao Zhao X X Shen Shen C C Zhu Zhu H H et al et al Trans-fatty acids aggravate obesity, insulin resistance and hepatic steatosis in C57BL/6 mice, possibly by suppressing the IRS1 dependent pathway Trans-fatty acids aggravate obesity, insulin resistance and hepatic steatosis in C57BL/6 mice, possibly by suppressing the IRS1 dependent pathway Molecules Molecules 2016 2016 21 21 6 6 1 1 11 11. The gene discussed is IRS1; the disease is fatty liver disease.