Izumiya Izumiya Y Y Hanatani Hanatani S S Kimura Kimura Y Y Growth Differentiation Factor-15 Is a Useful Prognostic Marker in Patients With Heart Failure With Preserved Ejection Fraction Growth Differentiation Factor-15 Is a Useful Prognostic Marker in Patients With Heart Failure With Preserved Ejection Fraction Can J Cardiol Can J Cardiol 2014 2014 30 30 3 3 338 338 344 344 24484911 24484911. The gene discussed is GDF15; the disease is heart failure.