GLI1 and neoplasm: For example, ZNF545, ZNF569, ZNF383, and ZNF331 are reported to act as tumor suppressor genes, while ZNF147, ZNF217, ZNF278, GLI1, and Evi9 promote tumor progression (Huang et al. 2006; Wang et al. 2013; Xiao et al. 2014; Yu et al. 2013).