The pharmacological inhibition of spinal PKCα (using a selective PKCα inhibitor peptide, C2-4) or genetic inhibition of PKCα (with antisense oligonucleotides) has both effectively reduced nociceptive hypersensitivity in animals, and also provided relief in pain-induced locomotive deficit and anxiety in persistent peripheral inflammation [22,76]. The gene discussed is PRKCA; the disease is Anxiety.