Mutations of TP53, CTNNB1, MEN1, and CDKN2A have been reported associated with ACC, and PRKAR1A, ZNRF3, RB1, APC, and RPL22 were also associated with ACC, based on recent researches (Zheng et al. 2016; Assié et al. 2014). The gene discussed is PRKAR1A; the disease is adrenal cortex carcinoma.