According to the above research data, we finally selected 9 genes associated with ACC as target genes, which were ZNRF3, TP53, CTNNB1, PRKAR1A, MEN1, RB1, APC, RPL22, and ARMC5, in order to explore mutation characteristics and clinical value of the target genes in ACC tissues. The gene discussed is RPL22; the disease is adrenal cortex carcinoma.