Those markers, such as α-inhibin, synaptophysin, melanA, calretinin, SF1, and so on, were mainly used to distinguish adrenocortical tumors from adrenal pheochromocytomas, adrenal metastases, or other types of retroperitoneal neoplasms, while those marker could not be regarded as specific markers for ACC. The gene discussed is SYP; the disease is adrenal cortex carcinoma.