Some past researches have demonstrated that mutations of TP53 gene, CTNNB1 gene, MEN1 gene, and CDKN2A gene might be associated with ACC (Juhlin et al. 2015; Gaujoux et al. 2008; Tissier et al. 2005; Barzon et al. 2001; Kjellman et al. 1999; Nobori et al. 1994). Here, TP53 is linked to adrenal cortex carcinoma.