According to the above research data, we finally selected 9 genes associated with ACC as target genes, which were ZNRF3, TP53, CTNNB1, PRKAR1A, MEN1, RB1, APC, RPL22, and ARMC5, in order to explore mutation characteristics and clinical value of the target genes in ACC tissues. Here, ZNRF3 is linked to adrenal cortex carcinoma.