RB1 and adrenal cortex carcinoma: The research identified several mutant genes associated with ACC, such as ZNRF3, CTNNB1, TP53, CDKN2A, RB1, and MEN1. In addition, it discovered that copy number variations of some genes were also related with ACC, such as amplification of TERT gene (5p.15.33), and homozygous deletion of CDKN2A (9p21.3), RB1 (13q14), and ZNRF3 (22q12.1).