Indeed, plasma levels of T-PA were found to be sixfold elevated in SARS-CoV-1 infection, suggesting potential endothelial injury.24A study in ICU COVID-19 patients demonstrated that non-ICU patients were characterized by both lower T-PA and PAI-1 levels than ICU patients.25In contrast, two case series with a total of eight cases of COVID-19 patients with ARDS showed beneficial results due to T-PA administration.26, 27In our cohorts in the ED, we found differences in the proportion of patients with pathological elevations between the four study groups for both T-PA and vWF. The gene discussed is SERPINE1; the disease is acute respiratory distress syndrome.