VWF and cancer: In addition to being a well-known independent predictor of atherothrombotic disease,39VWF has also been linked to various types of cancer and increased levels are associated with poor prognosis.40In line with this, a recent observational study in colorectal patients found that the lower levels of VWF were associated with improved event-free survival and less thrombotic complications.41Notably, the plasma concentration of VWF is increased among patients with malignant breast disease.42