F8 and cardiovascular disorder: In accordance with our findings, a large British prospective study of cardiovascular disease in 3,810 elderly men found that physical activity was significantly and inversely related with VWF in a dose–response manner.43In contrast to our study, the authors also found similar effects of physical activity on other hemostatic factors such as fibrinogen, platelet count, coagulation factors VIII and IX, D-dimer, and tissue plasminogen activator antigen, even after adjustment for possible confounders.