It was found that compared to BTLA Trs16859629Grs1982809Grs2171513Ars3112270 haplotype, the haplotype BTLA Trs16859629Ars1982809Grs2171513Grs3112270 significantly reduced the susceptibility to NSCLC (OR = 0.66, 95%CI = 0.659‐0.930, and P = 0.005). The gene discussed is BTLA; the disease is non-small cell lung carcinoma.