More specifically, the expression of this protein in African green monkey cell line and human hepatocellular carcinoma cell line can enhance the number of transcription factors binding to the promoter sequence of c-Fos and activate the transcription factor 2 (ATF2), cAMP-responsive element-binding protein 1 (CREB1), and FosB. The gene discussed is CREB1; the disease is hepatocellular carcinoma.