The HDV-associated HCC patients in GSE98383 had higher levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TB), prothrombin time (PT), platelet counts (PLT), and inflammatory activity grade than the HBV-associated HCC patients in GSE55092, which is consistent with the characteristics of CHD of the most severe hepatitis. The gene discussed is F2; the disease is hepatocellular carcinoma.